Naturally occuring antibodies against nerve growth factor in human and rabbit sera: comparison between control and herpes simplex virus-infected patients
| Autor: | V. Nerrière, Eleni Dicou, Vassiliki Labropoulou |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male viruses medicine.medical_treatment Immunology Enzyme-Linked Immunosorbent Assay medicine.disease_cause Virus Herpesviridae Alphaherpesvirinae medicine Animals Humans Immunology and Allergy Nerve Growth Factors Autoantibodies biology Herpes Simplex biology.organism_classification Virology Cytokine Herpes simplex virus Nerve growth factor nervous system Neurology biology.protein Immunohistochemistry Female Rabbits Neurology (clinical) Antibody |
| Zdroj: | Journal of Neuroimmunology. 34:153-158 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/0165-5728(91)90124-p |
| Popis: | Antibodies against nerve growth factor (NGF) in sera were detected by enzyme-linked immunosorbent assays (ELISA), by their isolation after passage of sera through NGF immunoadsorbent columns and by their specificity to bind and immunoprecipitate mouse NGF as well as to stain by immunohistochemical methods cellular sites of NGF synthesis. Increased levels of anti-NGF antibodies were found in sera of herpes simplex virus (HSV)-infected patients but not in HSV-inoculated rabbits. As HSV latency is known to be promoted by NGF in vitro, these results may suggest that anti-NGF antibodies modulate the cytokine function of NGF and thus might play a role in HSV infection. The biological function of circulating antibodies against NGF, in general, is now open to future investigation. |
| Databáze: | OpenAIRE |
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