New insights into erythropoietin and erythropoietin receptor in laryngeal cancer tissue
| Autor: | Renata Dobrila-Dintinjana, Blazen Marijic, Tamara Braut, Diana Marzic, Marko Velepic, Jelena Vukelić |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Otorhinolaryngology Cell Observational Study Statistics Nonparametric 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Receptors Erythropoietin Humans Medicine 030212 general & internal medicine Receptor Laryngeal Neoplasms Pathological Aged Aged 80 and over BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Oncology erythropoietin erythropoietin receptor head and neck cancer laryngeal cancer malignancy business.industry Cancer food and beverages BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Otorinolaringologija General Medicine Middle Aged medicine.disease Erythropoietin receptor medicine.anatomical_structure ROC Curve Erythropoietin 030220 oncology & carcinogenesis Cancer cell embryonic structures BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Onkologija Cancer research laryngeal cancer Immunohistochemistry Female head and neck cancer erythropoietin business erythropoietin receptor Research Article malignancy medicine.drug |
| Zdroj: | Medicine Volume 100 Issue 3 |
| ISSN: | 0025-7974 1536-5964 |
| Popis: | To investigate whether laryngeal cancer cells express erythropoietin (Epo) and erythropoietin receptor (EpoR) and what is their possible relationship with clinical and pathological features of the tumor. We performed immunohistochemical analysis of Epo and EpoR expression on 78 tissue samples of invasive and in situ squamous cell laryngeal carcinoma. The statistical analysis showed a weak positive and statistically significant correlation of EpoHS and EpoR HS expression levels. Epo HS and EpoR HS levels did not correlate with patient sex or age, type of diagnosis, cancer stage, histological tumor grade, presence or absence of disease recurrence, type of oncologic cancer therapy provided, or results of selected laboratory blood work. The results show a statistically significant difference in Epo expression with respect to survival. We confirmed the presence of Epo an EpoR in malignant laryngeal tumors and demonstrated the correlation between Epo expression and survival. Further studies are needed to more precisely define the role of Epo and EpoR in treatment of patients with laryngeal cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|