A kinetic study of human urinary excretion results for butobarbitone and its metabolites

Autor:	J. N. T. Gilbert, T. Natunen, L. Saunders, John Wesley Powell
Rok vydání:	1974
Předmět:	Male Pharmacology Chromatography Computers Metabolite Kinetics Pharmaceutical Science Urine Ketones Hydroxylation Excretion chemistry.chemical_compound Urinary excretion chemistry Barbiturates Humans Regression Analysis Limited capacity
Zdroj:	Journal of Pharmacy and Pharmacology. 26:16P-23P
ISSN:	2042-7158 0022-3573
DOI:	10.1111/j.2042-7158.1974.tb10072.x
Popis:	Experimentally determined concentrations of butobarbitone, and three or its metabolites, in the urine of two volunteers, have been studied using a computer technique, which tests the data for limited capacity or first order kinetics. In both volunteers, the 3′-hydroxy and the 3′-oxo metabolites follow limited capacity kinetics for the first few days of excretion, and unchanged butobarbitone follows first order kinetics. Differing results were found for the two persons with the 3′-carboxylic acid metabolite. An additional calculation is proposed when applying the Levy method for interpreting limited capacity kinetics to data where drug recovery is incomplete.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23883a9fe251bf1c935ba1ebbdaca8e6 https://doi.org/10.1111/j.2042-7158.1974.tb10072.x Zobrazit plný text záznamu Plný text