Suppression and facilitation of human neural responses
| Autor: | Anastasia V. Flevaris, Richard A.E. Edden, Michael-Paul Schallmo, Rachel Millin, Raphael Bernier, Alex Kale, Scott O. Murray, Zoran Brkanac |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Computer science Surround suppression Neural Inhibition GABA 0302 clinical medicine Psychophysics Biology (General) Visual Cortex media_common General Neuroscience 05 social sciences spatial vision General Medicine Healthy Volunteers surround suppression normalization Neural processing Facilitation Medicine Female Research Article Human Adult QH301-705.5 media_common.quotation_subject Science Models Neurological 050105 experimental psychology General Biochemistry Genetics and Molecular Biology Young Adult 03 medical and health sciences Neural activity Physical Stimulation Perception Humans 0501 psychology and cognitive sciences Motion perception Behavior General Immunology and Microbiology business.industry motion perception Visual motion MT Artificial intelligence business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | eLife, Vol 7 (2018) eLife |
| DOI: | 10.1101/174466 |
| Popis: | Efficient neural processing depends on regulating responses through suppression and facilitation of neural activity. Utilizing a well-known visual motion paradigm that evokes behavioral suppression and facilitation, and combining 5 different methodologies (behavioral psychophysics, computational modeling, functional MRI, pharmacology, and magnetic resonance spectroscopy), we provide evidence that challenges commonly held assumptions about the neural processes underlying suppression and facilitation. We show that: 1) both suppression and facilitation can emerge from a single, computational principle – divisive normalization; there is no need to invoke separate neural mechanisms, 2) neural suppression and facilitation in the motion-selective area MT mirror perception, but strong suppression also occurs in earlier visual areas, and 3) suppression is not driven by GABA-mediated inhibition. Thus, while commonly used spatial suppression paradigms may provide insight into neural response magnitudes in visual areas, they cannot be used to infer neural inhibition. |
| Databáze: | OpenAIRE |
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