Reversal of the antinociceptive effects of centrally-administered morphine by the benzodiazepine receptor antagonist Ro 15-1788
| Autor: | Sheila M. Muldoon, Robert S. Mansbach, James E. Barrett, David N. Skurdal, Linda S. Brady |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Flumazenil
Male (+)-Naloxone Pharmacology General Biochemistry Genetics and Molecular Biology Route of administration Mice Medicine Animals GABA-A Receptor Antagonists General Pharmacology Toxicology and Pharmaceutics Saimiri Benzodiazepinones Dose-Response Relationship Drug Morphine business.industry Naloxone General Medicine Dose–response relationship Nociception Systemic administration Opiate business medicine.drug |
| Zdroj: | Life sciences. 35(26) |
| ISSN: | 0024-3205 |
| Popis: | The effects of the benzodiazepine receptor antagonist, Ro 15-1788, were examined on analgesia induced by morphine after central (intracerebroventricular, i.c.v., or intrathecal, i.t.) and systemic administration. Analgesia was assessed in squirrel monkeys trained to respond under an electric shock titration procedure and in mice using the radiant heat tail-flick test. Central and systemic administration of morphine produced antinociceptive effects that were antagonized by 0.1 mg/kg of naloxone in both species. Ro 15-1788 antagonized the effects of morphine after central (i.c.v. or i.t.) administration but did not alter the effects of morphine given by the systemic route. This novel interaction suggests that Ro 15-1788 may be useful in pharmacologically separating neural substrates subserving opiate analgesia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|