The association between pentraxin 3 and insulin resistance in obese children at baseline and after physical activity intervention
| Autor: | Sang Hui, Chu, Ji-Hye, Park, Mi Kyung, Lee, Yoonsuk, Jekal, Ki Yong, Ahn, Jae Youn, Chung, Dong Hoon, Lee, Eun Sung, Kim, Masayo, Naruse, Jee-Aee, Im, In Deok, Kong, Deok, Kong, Choon Hee, Chung, Ji Won, Lee, Kyong-Mee, Chung, Young-Bum, Kim, Justin Y, Jeon |
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| Rok vydání: | 2012 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Clinical Biochemistry Subgroup analysis Overweight Biochemistry Body Mass Index Eating Insulin resistance Internal medicine medicine Humans Insulin Obesity Child Exercise Analysis of Variance business.industry Biochemistry (medical) Fasting General Medicine PTX3 medicine.disease Serum Amyloid P-Component C-Reactive Protein Endocrinology Female Analysis of variance Insulin Resistance medicine.symptom business Body mass index Homeostasis |
| Zdroj: | Clinica Chimica Acta. 413:1430-1437 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2012.06.002 |
| Popis: | Background The role of pentraxin-3 (PTX3) in the development of insulin resistance is still not clear. We aimed to test 1) whether circulating PTX3 levels are associated with insulin resistance and 2) whether changes in PTX3 levels after the physical activity are associated with changes in insulin resistance. Methods Fifty-seven overweight or obese children (39 boys, 18 girls; age: 12.04 ± 0.82 y, BMI: 26.5 ± 1.2 kg/m 2 ) participated in the study. All participants were housed together and their amount of physical activity (1823.5 ± 1.34 kcal/day) and food intake (1882 ± 68.8 kcal/day) were tightly controlled. Results Circulating PTX3 levels at baseline were negatively associated with fasting insulin ( r = − .336, p = 0.012) and homeostasis model assessment of insulin resistance (HOMA-IR) ( r = − .334, p = 0.014) even after adjustment for BMI and Tanner stage. The degree of change in PTX3 levels notably associated with changes in fasting insulin ( r = − .280, p = 0.035) and HOMA-IR ( r = − .281, p = .034) in response to the physical activity intervention. Subgroup analysis further indicates that HOMA-IR was improved more in subjects whose PTX3 levels were increased compared with subjects who PTX3 levels were decreased (HOMA-IR delta: − 2.33 ± 1.3 vs − 1.46 ± 0.70, p = 0.004). Conclusion PTX3 is negatively associated with insulin resistance and associated with changes in insulin resistance induced by physical activity in overweight and obese children. |
| Databáze: | OpenAIRE |
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