Plasmodium falciparum -Specific Cellular Immune Responses after Immunization with the RTS,S/AS02D Candidate Malaria Vaccine in Infants Living in an Area of High Endemicity in Mozambique
| Autor: | Pedro L. Alonso, Inacio Mandomando, M. Nelia Manaca, Sarah Lafuente, Denise Naniche, Arnoldo Barbosa, John J. Aponte, W. Ripley Ballou, Pedro Aide, Jahit Sacarlal, Montse Renom |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Cellular immunity Plasmodium falciparum Immunology Protozoan Proteins CD8-Positive T-Lymphocytes Microbiology Placebos Interferon-gamma Pregnancy T-Lymphocyte Subsets Malaria Vaccines parasitic diseases medicine Animals Humans Malaria Falciparum Mozambique biology Malaria vaccine Infant Newborn RTS S Infant biology.organism_classification medicine.disease Virology Circumsporozoite protein Vaccination Infectious Diseases Immunization Leukocytes Mononuclear Interleukin-2 Female Parasitology Interleukin-4 Fungal and Parasitic Infections Malaria |
| Zdroj: | Infection and Immunity. 77:4502-4509 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.00442-09 |
| Popis: | Results from clinical trials in areas where malaria is endemic have shown that immunization with RTS,S/AS02A malaria vaccine candidate induces partial protection in adults and children and cellular effector and memory responses in adults. For the first time in a malaria vaccine trial, we sought to assess the cell-mediated immune responses to RTS,S antigen components in infants under 1 year of age participating in a clinical phase I/IIb trial of RTS,S/AS02D in Mozambique. Circumsporozoite protein (CSP)-specific responses were detected in approximately half of RTS,S-immunized infants and included gamma interferon (IFN-γ), interleukin-2 (IL-2), and combined IL-2/IL-4 responses. The median stimulation indices of cytokine-producing CD4 + and CD8 + cells were very low but significantly higher in RTS,S-immunized infants than in infants that received the comparator vaccine. Protection against subsequent malarial infection tended to be associated with a higher percentage of individuals with CSP-specific IL-2 in the supernatant ( P = 0.053) and with higher CSP-specific IFN-γ-producing CD8 + T-cell responses ( P = 0.07). These results report for the first time the detection of malaria-specific cellular immune responses after vaccination of infants less than 1 year of age and pave the way for future field studies of cellular immunity to malaria vaccine candidates. |
| Databáze: | OpenAIRE |
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