Impaired repletion of intramyocellular lipids in patients with growth hormone deficiency after a bout of aerobic exercise
| Autor: | Julie Bucher, Hannah Loher, Christoph Hans Boesch, Roland Kreis, Marion Krüsi, Emanuel Christ, Stefan Jenni |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Waist Endocrinology Diabetes and Metabolism Subcutaneous Fat 030209 endocrinology & metabolism Intra-Abdominal Fat Growth hormone Subcutaneous fat Growth hormone deficiency 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Humans Aerobic exercise In patient Prospective Studies Intramyocellular lipids Muscle Skeletal Exercise Growth Disorders Human Growth Hormone business.industry Middle Aged medicine.disease Control subjects Lipids 030104 developmental biology Case-Control Studies business |
| Zdroj: | Growth Hormone & IGF Research. :32-39 |
| ISSN: | 1096-6374 |
| DOI: | 10.1016/j.ghir.2018.08.001 |
| Popis: | Background Ectopic lipids such as intramyocellular lipids (IMCL) are depleted by exercise and repleted by diet, whereas intrahepatocellular lipids (IHCL) are increased immediately after exercise. So far, it is unclear how ectopic lipids behave 24 h after exercise and whether the lack of growth hormone (GH) significantly affects ectopic lipids 24 h after exercise. Methods Seven male patients with growth hormone deficiency (GHD) and seven sedentary male control subjects (CS) were included. VO2max was assessed by spiroergometry; visceral and subcutaneous fat by whole body MRI. 1H-MR-spectroscopy was performed in M. vastus intermedius and in the liver before and after 2 h of exercise at 50% VO2max and 24 h thereafter, while diet and physical activity were standardized. Results Sedentary male subjects (7 GHD, 7 CS) were recruited. Age, BMI, waist circumference, visceral and subcutaneous fat mass was not significantly different between GHD and CS. VO2max was significantly lower in GHD vs. CS. IMCL were diminished through aerobic exercise in both groups: (−11.5 ± 21.9% in CS; −8.9% ±19.1% in GHD) and restored after 24 h in CS (−5.5 ± 26.6% compared to baseline) but not in GHD (−17.9 ± 15.3%). IHCL increased immediately after exercise and decreased to baseline within 24 h. Conclusion These findings suggest that GHD may affect repletion of IMCL 24 h after aerobic exercise. |
| Databáze: | OpenAIRE |
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