Fibronectin is a hypoxia-independent target of the tumor suppressor VHL

Autor: Maartje Los, Moniek van Beest, Frank C. P. Holstege, Martijn F.B.G. Gebbink, Cristel M.J.T. Snijckers, Emile E. Voest, Hans A.R. Bluyssen, Martijn P. Lolkema, Michelle Boone, Branko Braam, Rachel H. Giles
Rok vydání: 2004
Předmět:
Transcription
Genetic
endocrine system diseases
Microarray
urologic and male genital diseases
Biochemistry
law.invention
Structural Biology
law
Tumor Cells
Cultured
Genes
Tumor Suppressor
Hypoxia
Regulation of gene expression
biology
Vascular Endothelial Growth Factors
Chemistry
Ceruloplasmin
Transfection
Cell Hypoxia
Recombinant Proteins
female genital diseases and pregnancy complications
Renal cell carcinoma
Up-Regulation
Gene Expression Regulation
Neoplastic
Von Hippel-Lindau Tumor Suppressor Protein
Tumor suppressor gene
Ubiquitin-Protein Ligases
Biophysics
Downregulation and upregulation
VHL
Genetics
Humans
RNA
Messenger
Carcinoma
Renal Cell
Molecular Biology
neoplasms
Fibronectin
Gene Expression Profiling
Tumor Suppressor Proteins
Wild type
Cell Biology
Molecular biology
Fibronectins
Gene expression profiling
Renal disorders [UMCN 5.4]
Insulin-Like Growth Factor Binding Protein 3
Cancer research
biology.protein
Suppressor
Zdroj: FEBS Letters, 556, 1-3, pp. 137-42
FEBS Letters, 556, 137-42
ISSN: 0014-5793
Popis: Item does not contain fulltext The von Hippel-Lindau (VHL) tumor suppressor gene regulates the extracellular matrix by controlling fibronectin deposition. To identify novel VHL target genes, we subjected mRNA from VHL-deficient RCC cells (786-0-pRC) and a transfectant re-expressing wildtype VHL (786-0-VHL) to differential expression profiling. Among the differentially expressed genes, we detected that fibronectin is upregulated in the presence of VHL, while it is not affected by hypoxia. Thus regulation of fibronectin deposition by VHL occurs at the transcriptional level, irrespective of oxygen levels.
Databáze: OpenAIRE
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