Inception Mechanisms of Tunneling Nanotubes
| Autor: | David Stopar, Aleš Iglič, Veronika Kralj-Iglič, Mitja Drab |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Materials science anizotropne membranske inkluzije filopodija Nanotechnology Review tunneling nanotubes Membrane bending Motor protein anisotropic membrane domains 03 medical and health sciences filopodia 0302 clinical medicine udc:577 Cytoskeleton lcsh:QH301-705.5 Unilamellar Liposomes Quantum tunnelling Nanotubes citoskeletne sile General Medicine 030104 developmental biology Membrane lcsh:Biology (General) 030220 oncology & carcinogenesis nanotube Anisotropy cytoskeletal forces Cell Surface Extensions f-actin Filopodia f-aktin |
| Zdroj: | Cells Cells, vol. 8, no. 6, 626, 2019. Cells, Vol 8, Iss 6, p 626 (2019) |
| ISSN: | 2073-4409 |
| DOI: | 10.5281/zenodo.3491877 |
| Popis: | Tunneling nanotubes (TNTs) are thin membranous tubes that interconnect cells, representing a novel route of cell-to-cell communication and spreading of pathogens. TNTs form between many cell types, yet their inception mechanisms remain elusive. We review in this study general concepts related to the formation and stability of membranous tubular structures with a focus on a deviatoric elasticity model of membrane nanodomains. We review experimental evidence that tubular structures initiate from local membrane bending facilitated by laterally distributed proteins or anisotropic membrane nanodomains. We further discuss the numerical results of several theoretical and simulation models of nanodomain segregation suggesting the mechanisms of TNT inception and stability. We discuss the coupling of nanodomain segregation with the action of protruding cytoskeletal forces, which are mostly provided in eukaryotic cells by the polymerization of f-actin, and review recent inception mechanisms of TNTs in relation to motor proteins. |
| Databáze: | OpenAIRE |
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