1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors

Autor:	Robert Hughes, Michael B. Tollefson, Michael John Palmer, Brad A. Acker, Brian R. Bond, Fox David Nathan Abraham, Ying Yu, E. J. Jacobsen, John K. Walker, Sandra K. Freeman
Rok vydání:	2010
Předmět:	medicine.drug_mechanism_of_action Stereochemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Chemical synthesis Structure-Activity Relationship Dogs In vivo Drug Discovery medicine Animals Humans Potency Enzyme Inhibitors Molecular Biology Cyclic Nucleotide Phosphodiesterases Type 5 chemistry.chemical_classification Bicyclic molecule biology Organic Chemistry Phosphodiesterase 5 Inhibitors Pyrimidines Enzyme chemistry Enzyme inhibitor cGMP-specific phosphodiesterase type 5 Microsomes Liver biology.protein Molecular Medicine Phosphodiesterase 5 inhibitor
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 20:3120-3124
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2010.03.111
Popis:	1H-Pyrazolo[4,3-d]pyrimidines are a class of potent and selective second generation phosphodiesterase 5 (PDE5) inhibitors. This work explores the potency, selectivity and efficacy of 1-(2-ethoxyethyl)-1H-pyrazolo[4,5-d]pyrimidines as PDE5 inhibitors resulting in the advancement of a clinical candidate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237d1b41e2f31e4be9891479b99bb481 https://doi.org/10.1016/j.bmcl.2010.03.111 Zobrazit plný text záznamu Full Text from ScienceDirect