Congenital chromosome breakage clusters within Giemsa-light bands and identifies sites of chromatin instability
| Autor: | Raju S.K. Chaganti, Prasad Koduru |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Genetic Markers
medicine.medical_specialty Biology Azure Stains Chromosome regions Proto-Oncogenes Genetics medicine Humans Molecular Biology Genetics (clinical) Chromosomal inversion Chromosome Aberrations Autosome Chromosome Fragile Sites Chromosome Fragility Cytogenetics Chromosome Molecular biology Chromatin Chromosome Banding Karyotyping Chromosome breakage Satellite chromosome |
| Zdroj: | Cytogenetic and Genome Research. 49:269-274 |
| ISSN: | 1424-859X 1424-8581 |
| Popis: | Analysis of the distribution of published chromosome breaks in cells with constitutional chromosome aberrations showed a nonrandom distribution of breaks among chromosomes and chromosome regions. A significant amount of breakage occurred at Giemsa-negative bands. In addition, chromosome sites associated with a number of fragile sites and cellular oncogene sites were affected nonrandomly. The data are consistent with the hypothesis that chromosome breakage occurs in somatic or germ cells as a result of recombinational errors involving actively transcribing chromatin regions or regions of unstable DNA sequence structure placed in proximity during interphase. |
| Databáze: | OpenAIRE |
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