Effects of nicotine, pilocarpine, and tetrahydroaminoacridine on hippocampal theta waves in freely moving rabbits
| Autor: | Jyunji Yamamoto |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Agonist
Male medicine.medical_specialty Nicotine medicine.drug_class Hippocampus Hippocampal formation Muscarinic Agonists Internal medicine Muscarinic acetylcholine receptor medicine Animals Nicotinic Agonists Theta Rhythm Pharmacology Cerebral Cortex Dose-Response Relationship Drug Chemistry Pilocarpine Electroencephalography Endocrinology Nicotinic agonist Tacrine Cholinesterase Inhibitors Rabbits medicine.drug |
| Zdroj: | European journal of pharmacology. 359(2-3) |
| ISSN: | 0014-2999 |
| Popis: | The effects of three cholinergic agents on hippocampal theta waves were investigated by analyzing electroencephalographic power spectra in freely moving rabbits. In the hippocampal spectra, nicotine (a nicotinic receptor agonist, 0.03 mg/kg) increased the theta wave frequency, but caused no change in its power. Pilocarpine (a muscarinic receptor agonist, 0.3 and 1.0 mg/kg) and tetrahydroaminoacridine (a cholinesterase inhibitor, 3.0 mg/kg) increased the power and deceased the frequency. These results suggest that the activating effect of nicotinic receptor agonists on the hippocampus may be different from that of muscarinic receptor agonists or cholinesterase inhibitors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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