Bacterial endotoxin-induced expression of metallothionein genes in rat brain, as revealed by in situ hybridization
| Autor: | Katsuhiko Ono, Sumihare Noji, Shigehiko Taniguchi, Toru Takahashi, Futami Kosaka, Eiki Koyama, Naoyuki Taga, Yoshitaro Itano |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Lipopolysaccharides
Male Cerebellum Pathology medicine.medical_specialty Ependymal Cell Lipopolysaccharide Central nervous system In situ hybridization Biology chemistry.chemical_compound Gene expression medicine Metallothionein Animals RNA Messenger Gene Brain Chemistry General Neuroscience Nucleic Acid Hybridization Rats Inbred Strains Molecular biology Rats Endotoxins Zinc medicine.anatomical_structure chemistry Gene Expression Regulation Acute-Phase Proteins |
| Zdroj: | Neuroscience letters. 124(1) |
| ISSN: | 0304-3940 |
| Popis: | In order to clarify acute-phase response in brain, we investigated induction of metallothionein (MT) genes by administrating an endotoxin (lipopolysaccharide) in rat intraperitoneum. We performed in situ hybridization on the serial brain sections to identify the cells expressing the MT genes in acute-phase. After endotoxin administration, transcripts of MT genes were detected in the arachnoideal, ependymal cells and glial cells around the Purkinje cells of the cerebellum, while no significant induction of the MT genes by zinc ion was observed in brain. These results suggest that the acute-phase response occurs specifically in at least these 3 non-neuronal cells. |
| Databáze: | OpenAIRE |
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