Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker?
| Autor: | Timothy G. Dinan, Siobhan M O'Mahony, P. W Napoleon Keeling, Fergus Shanahan, Eamonn Martin Quigley, Paul Scully, Salah M M Ahmed, Sinead O'Brien, Liam O'Mahony |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Hypothalamo-Hypophyseal System Alcohol Drinking medicine.medical_treatment Pain Adrenocorticotropic hormone Dexamethasone Proinflammatory cytokine Irritable Bowel Syndrome Corticotropin-releasing hormone Adrenocorticotropic Hormone Reference Values Internal medicine Medicine Humans Irritable bowel syndrome Hepatology business.industry Interleukin-6 Interleukin-8 Gastroenterology Interleukin medicine.disease Interleukin-10 Intestines Cytokine medicine.anatomical_structure Endocrinology Cytokines Female business Ireland hormones hormone substitutes and hormone antagonists Hypothalamic–pituitary–adrenal axis Biomarkers medicine.drug |
| Zdroj: | Gastroenterology. 130(2) |
| ISSN: | 0016-5085 |
| Popis: | Background & Aims: Irritable bowel syndrome (IBS) is a functional disorder with an etiology that has been linked to both psychological stress and infection. The primary aim of this study was to examine the hypothalamic-pituitary-adrenal axis in patients with IBS and to relate such response to plasma cytokine profiles. Methods: A total of 151 subjects, 76 patients and 75 controls, were recruited. The patients with IBS were diagnosed according to Rome II criteria. Forty-nine patients and 48 matched controls had cytokine levels measured, and a subset of 21 patients and 21 controls also underwent a corticotropin-releasing hormone (CRH) stimulation test with plasma levels of adrenocorticotropic hormone (ACTH) and cortisol measured. The remaining 27 patients and 27 controls underwent a dexamethasone (1 mg) challenge. Results: Cortisol and the proinflammatory cytokines interleukin (IL)-6 (together with its soluble receptor) and IL-8 were elevated in all IBS subgroups (diarrhea predominant, constipated, and alternators), although the elevation was most marked in the constipated subgroup. There was no alteration in the anti-inflammatory cytokine IL-10. Following CRH infusion, an exaggerated release of both ACTH and cortisol was observed in patients with IBS. There was a significant correlation between the ACTH response (δACTH) and the IL-6 levels. A similar relationship existed between the δACTH/δcortisol ratio and the IL-6 levels. Dexamethasone suppression of cortisol was similar in patients and controls. Conclusions: IBS is characterized by an overactivation of the hypothalamic-pituitary-adrenal axis and a proinflammatory cytokine increase. |
| Databáze: | OpenAIRE |
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