Significance of Expression of Cancer Stem Cell Markers CD133 and Nestin in Pancreatic Intraepithelial Carcinoma-invasive Adenocarcinoma Sequence
| Autor: | Hanan AlSaeid Alshenawy |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Histology endocrine system diseases Adenocarcinoma Pathology and Forensic Medicine Metastasis Causes of cancer Nestin 03 medical and health sciences 0302 clinical medicine Cancer stem cell Biomarkers Tumor Medicine Humans Neoplasm Invasiveness AC133 Antigen Stage (cooking) Neoplasm Metastasis Aged Aged 80 and over business.industry Cancer Middle Aged medicine.disease digestive system diseases Neoplasm Proteins Pancreatic Neoplasms Medical Laboratory Technology 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Neoplastic Stem Cells Female Intraepithelial carcinoma business Carcinoma in Situ |
| Zdroj: | Applied immunohistochemistrymolecular morphology : AIMM. 28(3) |
| ISSN: | 1533-4058 |
| Popis: | Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies and one of the most leading causes of cancer related deaths. It has a very poor prognosis with high recurrence rate. We investigated the expression of CSC markers (CD133 and nestin) in 100 patients [30 pancreatic intraepithelial tumor cases (PanIN) and 70 PDAC cases] and correlate the expression levels of these markers with clinicopathological data with the aid of Ki67 expression. Our findings showed that both cancer stem markers are related to the grade, stage, metastasis of PDAC and to the grade of PanIN cases and revealed that both markers are associated with PanIN-PDAC sequence with inverse relation between them. Both markers may contribute to proliferation, differentiation, invasiveness, and histologic types of PDAC. Sothey may also be useful for developing new therapeutic modalities for PDAC. |
| Databáze: | OpenAIRE |
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