Viral infection potentiates the increase in airway blood flow produced by substance P
Autor: | J. A. Nadel, Claude Bertrand, Isao Yamawaki, Pierangelo Geppetti, G. Piedimonte, Pierre P. Massion, Brendan Chan |
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Rok vydání: | 1995 |
Předmět: |
Male
Captopril Physiology Respiratory System Down-Regulation Hemodynamics Angiotensin-Converting Enzyme Inhibitors Peptidyl-Dipeptidase A Substance P Pharmacology Biology chemistry.chemical_compound Physiology (medical) medicine Animals Protease Inhibitors Paramyxoviridae Infections Phosphoramidon Glycopeptides Angiotensin-converting enzyme Blood flow respiratory system Microspheres Rats Inbred F344 Parainfluenza Virus 1 Human Rats medicine.anatomical_structure chemistry Regional Blood Flow ACE inhibitor Immunology biology.protein Neprilysin Histamine medicine.drug Respiratory tract |
Zdroj: | Journal of Applied Physiology. 79:398-404 |
ISSN: | 1522-1601 8750-7587 |
Popis: | We examined the effect of respiratory tract infection with Sendai virus on the responsiveness of airway blood flow to substance P (SP) in rats. Pathogen-free rats were inoculated with either Sendai virus suspension or sterile viral growth medium into each nostril. Five days later, we measured airway and esophageal blood flows before and immediately after injection of SP or histamine into the left ventricle of rats in both groups using a modification of the reference-sample microsphere technique. Viral infection potentiated the increase in airway blood flow evoked by SP but not by histamine. We also examined the effect of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE) on the SP-induced increase in airway blood flow. Both phosphoramidon (NEP inhibitor) and captopril (ACE inhibitor) potentiated the increase in airway blood flow produced by SP in pathogen-free rats. In the presence of both peptidase inhibitors, a submaximal dose of SP increased blood flow to a similar level in infected and pathogen-free rats. Thus decreased activity of both ACE and NEP may be involved in the exaggerated increase in airway blood flow evoked by SP in virus-infected rats. |
Databáze: | OpenAIRE |
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