Suppression of tumor growth by palm tocotrienols via the attenuation of angiogenesis
| Autor: | Kanga Rani Selvaduray, Cheng Hwee Ming, Wong Weng-Yew, Kalanithi Nesaretnam |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Vascular Endothelial Growth Factor A
Cancer Research Angiogenesis Medicine (miscellaneous) Angiogenesis Inhibitors Biology Pharmacology Palm Oil Umbilical vein Chorioallantoic Membrane chemistry.chemical_compound Mice In vivo Cell Movement Cell Line Tumor Animals Anticarcinogenic Agents Humans Plant Oils Cell Proliferation Mice Inbred BALB C Nutrition and Dietetics Cell growth Tocotrienols Endothelial Cells Cell migration Vascular endothelial growth factor Chorioallantoic membrane Oncology chemistry Cell culture Immunology Female Chickens |
| Zdroj: | Nutrition and cancer. 61(3) |
| ISSN: | 1532-7914 |
| Popis: | Previous studies have revealed that tocotrienol-rich fractions (TRF) from palm oil inhibit the proliferation and the growth of solid tumors. The anticancer activity of TRF is said to be caused by several mechanisms, one of which is antiangiogenesis. In this study, we looked at the antiangiogenic effects of TRF. In vitro investigations of the antiangiogenic activities of TRF, delta-tocotrienol (deltaT3), and alpha-tocopherol (alphaToc) were carried out in human umbilical vein endothelial cells (HUVEC). TRF and deltaT3 significantly inhibited cell proliferation from 4 microg/ml onward (P < 0.05). Cell migration was inhibited the most by deltaT3 at 12 microg/ml. Anti-angiogenic properties of TRF were carried out further in vivo using the chick embryo chorioallantoic membrane (CAM) assay and BALB/c mice model. TRF at 200 microg/ml reduced the vascular network on CAM. TRF treatment of 1 mg/mouse significantly reduced 4T1 tumor volume in BALB/c mice. TRF significantly reduced serum vascular endothelial growth factor (VEGF) level in BALB/c mice. In conclusion, this study showed that palm tocotrienols exhibit anti-angiogenic properties that may assist in tumor regression. |
| Databáze: | OpenAIRE |
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