Association between antimicrobial treatment and resistance of pathogenic Escherichia coli isolated from diseased swine in Kagoshima Prefecture, Japan
| Autor: | Taruho Funamori, Jiro Iwamoto, Masahiro Kusumoto, Kyohei Hamada, Wakako Misumi, Shoichiro Fujisono, Kenichi Chitose |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cefotaxime
040301 veterinary sciences Swine Virulence Microbial Sensitivity Tests beta-Lactamases Microbiology pathogenic Escherichia coli 0403 veterinary science 03 medical and health sciences Antibiotic resistance Anti-Infective Agents Japan Pathogenic Escherichia coli Ampicillin Drug Resistance Bacterial medicine Escherichia coli Animals antimicrobial resistance Escherichia coli Infections 030304 developmental biology 0303 health sciences General Veterinary biology Full Paper Bacteriology 04 agricultural and veterinary sciences biology.organism_classification Antimicrobial Anti-Bacterial Agents Streptomycin Ceftiofur medicine.drug |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 0916-7250 |
| Popis: | Pathogenic Escherichia coli is an important cause of diarrhea, edema disease, and septicemia in swine. In Japan, the volume of antimicrobial drugs used for animals is highest in swine, but information about the prevalence of antimicrobial-resistant bacteria is confined to apparently healthy animals. In the present study, we determined the O serogroups, virulence factors, and antimicrobial resistance of 360 E. coli isolates from swine that died of disease in Kagoshima Prefecture, Japan, between 1999 and 2017. The isolates of the predominant serogroups O139, OSB9, O149, O8, and O116 possessed virulence factor genes typically found in diarrheagenic E. coli. We further found five strains of third-generation cephalosporin-resistant E. coli that each produced an extended-spectrum β-lactamase encoded by blaCTX-M-14, blaCTX-M-15, blaCTX-M-24, blaCTX-M-61, or blaSHV-12. In 218 swine with a clear history of antimicrobial drug use, we further analyzed associations between the use of antimicrobials for the treatment of diseased swine and the isolation of resistant E. coli. We found significant associations between antimicrobial use and selection of resistance to the same class of antimicrobials, such as the use of ceftiofur and resistance to cefotaxime, cefazolin, or ampicillin, the use of aminoglycosides and resistance to streptomycin, and the use of phenicols and resistance to chloramphenicol. A significant association between antimicrobial use and the resistance of E. coli isolates to structurally unrelated antimicrobials, such as the use of ceftiofur and resistance to chloramphenicol, was also observed. |
| Databáze: | OpenAIRE |
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