The assessment of environmental and external cross-contamination in preparing ready-to-administer cytotoxic drugs: a comparison between a robotic system and conventional manual production
| Autor: | Tjerk H Geersing, Mirjam Crul, Annabel Werumeus Buning |
|---|---|
| Přispěvatelé: | Clinical pharmacology and pharmacy |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Chromatography
Gas environmental contamination Drug Compounding Pharmaceutical Science Antineoplastic Agents Pharmacy 030226 pharmacology & pharmacy Preparation method 03 medical and health sciences 0302 clinical medicine Tandem Mass Spectrometry Medicine Humans Cyclophosphamide Waste management business.industry Health Policy Public Health Environmental and Occupational Health technology industry and agriculture automated compounding surface contamination Robotics Contamination Research Papers wipe sampling robotic preparation Robotic systems Compounding 030220 oncology & carcinogenesis robotic system cytotoxic drugs Equipment Contamination Fluorouracil business Drug Contamination Pharmacy Service Hospital hazardous drugs Wipe sampling Research Paper |
| Zdroj: | International Journal of Pharmacy Practice, 28(1), 66-74. Wiley-Blackwell The International Journal of Pharmacy Practice Werumeus Buning, A, Geersing, T H & Crul, M 2020, ' The assessment of environmental and external cross-contamination in preparing ready-to-administer cytotoxic drugs : a comparison between a robotic system and conventional manual production ', International Journal of Pharmacy Practice, vol. 28, no. 1, pp. 66-74 . https://doi.org/10.1111/ijpp.12575 |
| ISSN: | 0961-7671 |
| DOI: | 10.1111/ijpp.12575 |
| Popis: | Objectives The primary aim of the study was to compare environmental and external (cross-) contamination of traces of cytostatics, during preparation of 5-fluorouracil and cyclophosphamide using a robotic system (APOTECAchemo) or the conventional manual compounding procedure. The secondary aim was to validate the cleaning procedure of the robot. Methods Eighty ready-to-administer (RTA) infusion bags with 5-fluorouracil, cyclophosphamide or sodium chloride were compounded using both techniques on 3–5 days. Wipe samples were taken from several locations in the compounding room before and after cleaning, and also from the technician’s gloves. These samples were analysed for 5-fluorouracil and cyclophosphamide concentrations using GC/MS/MS. Key findings A total of 284 wipe samples were collected during the study (113 from the manual and 171 from the robotic process). External contamination on the outside of infusion bags was 3.75% for both manual and robotic compounding. For manual compounding, external cross-contamination occurred on 2.5% of the prepared infusion bags. External cross-contamination occurred on 1.25% of the infusion bags for the robotic procedure. Inside the compounding room, 9% of the environmental wipe samples were contaminated in case of manual production and 24% for robotic compounding. Since 50% of the contaminated environmental samples for the robotic system were taken after cleaning, the cleaning procedure was extended and parameter setting for cyclophosphamide handling was performed. After this, residual environmental or external contamination was no longer detectable. Conclusion Comparison of both preparation methods showed that external (cross-)contamination of infusion bags was lower using the robotic system. An optimized cleaning procedure showed the best results in environmental contamination for the robot. |
| Databáze: | OpenAIRE |
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