Multiple cerebral infarction diagnosed as Eosinophilic Granulomatosis with Polyangiitis by autopsy

Autor: Mizuho Sugiyama, Takao Urabe, Hideki Shimura, Keiji Takahashi, Masashi Takanashi, Nobutaka Hattori, Riyu Kamata, Hiroshi Izumi, Kenichiro Hira, Akane Hashizume
Rok vydání: 2019
Předmět:
Zdroj: BMC Neurology, Vol 19, Iss 1, Pp 1-4 (2019)
BMC Neurology
ISSN: 1471-2377
DOI: 10.1186/s12883-019-1515-z
Popis: Background Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis of unknown cause involving the brain and accompanied by prominent eosinophilia. Intracardiac thrombosis is a major cardiac complication of EGPA that may cause thromboembolism. Case presentation A 53-year-old man presenting with abulia (consciousness disturbance) and left upper limb paralysis was admitted to our hospital. His case was complicated by penetrating branches, small vessel infarcts, and endocardial thrombosis in the right and left ventricle. Cardiomyopathy was also observed. Sixteen days after admission, the patient died from intracranial hemorrhage. Brain autopsy revealed two major findings: 1) large hemorrhagic infarction caused by cardiac embolism; and 2) granuloma and eosinophil infiltration. Vasculitis was accompanied by eosinophil infiltration in the cortical blood vessels and granuloma. Conclusions In this case study, we report autopsy findings of brain infarction in a patient with EGPA and endocardial thrombosis. The brain infarction was caused by the cardiac embolisms and vasculitis.
Databáze: OpenAIRE
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