Increased systemic immune-inflammation index independently predicts poor survival for hormone receptor-negative, HER2-positive breast cancer patients
| Autor: | Yi Sun, Ai-Jie Li, Jinbo Yue, Wenqiang Li, Jinming Yu, Huichao Su |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Multivariate analysis Lymphocyte Gastroenterology 03 medical and health sciences breast cancer 0302 clinical medicine Breast cancer HER2 Internal medicine Statistical significance Medicine Prospective cohort study Original Research business.industry Proportional hazards model medicine.disease SII 030104 developmental biology medicine.anatomical_structure Oncology inflammation Cancer Management and Research Hormone receptor 030220 oncology & carcinogenesis business Hormone |
| Zdroj: | Cancer Management and Research |
| ISSN: | 1179-1322 |
| Popis: | Yi Sun,1 Wenqiang Li,2 Ai-Jie Li,2 Huichao Su,1 Jinbo Yue,1,3 Jinming Yu1,31Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, Shandong 250117, People’s Republic of China; 2Department of Radiation Oncology, Weifang Medical University, Weifang, Shandong, 261053, People’s Republic of China; 3School of Medicine and Life Sciences, Shandong Academy of Medical Sciences, Jinan, Shandong, 250000, People’s Republic of ChinaPurpose: We sought to examine the role of pretreatment systemic immune-inflammation index (SII) in hormone receptor-negative, human epidermal growth factor receptor 2+ (HER2+) breast cancer patients.Patients and methods: 155 HER2+ patients treated in our hospital from September 3, 2002, to September 21, 2012, were retrospectively enrolled. SII was established as neutrophil x platelet/lymphocyte counts. The median value of SII was used as cut-off value. We used the Kaplan-Meier method to evaluate the overall survival (OS), disease-free survival (DFS), distant metastasis-free survival (DMFS). To comparatively evaluate the survival rates between patients from two groups, we used the log-rank test. For identifying independent factors of prognosis, we used the Cox regression model, applying multivariate statistics.Results: Analyses show that HER2+ patients with high and low SII had median DFS of 15.1 and 31.5months, respectively (P |
| Databáze: | OpenAIRE |
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