Risk Groups of Developing Active Tuberculosis in Liver Transplant Recipients in a Tuberculosis Endemic Area: Risk Stratification by Chest Image and Interferon Gamma Release Assay
| Autor: | Cheol-In Kang, Sun Young Cho, Eliel Nham, Jong Man Kim, Suhyun Oh, Kyungmin Huh, Kyong Ran Peck, Si-Ho Kim, Jae-Won Joh, Jae-Hoon Ko, Gyu-Seong Choi, Doo Ryeon Chung |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Tuberculosis Chest image medicine.medical_treatment Interferon-gamma release assay Interferon gamma release assay Infectious and parasitic diseases RC109-216 Liver transplantation Risk Assessment Risk groups Latent Tuberculosis Risk Factors Internal medicine medicine Humans Latent tuberculosis infection Risk factor Retrospective Studies Tuberculin Test Proportional hazards model business.industry Retrospective cohort study General Medicine medicine.disease Liver Transplantation Transplantation Infectious Diseases business Interferon-gamma Release Tests |
| Zdroj: | International Journal of Infectious Diseases, Vol 113, Iss, Pp 359-366 (2021) |
| ISSN: | 1201-9712 |
| DOI: | 10.1016/j.ijid.2021.10.043 |
| Popis: | Objectives : We implemented a stratified risk analysis to predict the development of active tuberculosis (TB) in liver transplantation (LT) recipients based on IGRA and chest images in the TB-endemic area. Methods In this retrospective cohort study, LT recipients who tested for IGRA between May 2008 and December 2017 were included. Chest images compatible with old TB lesions were considered as positive images. LT recipients were divided into six groups: LT recipients with history of treated TB, image (+)/IGRA (+), image (+)/IGRA (-), image (-)/IGRA (+), image (-)/IGRA (-) and LTBI treated. The Cox regression model was used to analyze risk groups. Results Among the 717 eligible LT recipients included in this study, 21 patients developed active TB. Incidence rates of TB were 2,261, 724, and 119 cases/100,000 person-years in the 1st, 2nd, and ≥ 3rd year after transplantation, respectively. History of treated TB (HR 18.92; 95% CI 4.10–87.25) and image (+)/IGRA (+) (HR 10.86; 95% CI 2.75–42.89) were independent risk factors for developing active TB. IGRA (+) with a negative image was not a risk factor. Conclusions Our findings suggested that both IGRA and chest images should be considered to identify risk groups for LTBI treatment. |
| Databáze: | OpenAIRE |
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