Investigation of a Novel Multicomponent Mycotoxin Detoxifying Agent in Amelioration of Mycotoxicosis Induced by Aflatoxin-B1 and Ochratoxin A in Broiler Chicks
| Autor: | Panagiotis Tassis, Nikola Delić, Tilemachos Mantzios, Evanthia Petridou, I. Georgopoulou, Marko Vasiljević, Vasilios Tsiouris, Nikolaos Mittas, Zoe S. Polizopoulou, Konstantinos Kiskinis, Georgia Brellou, Jog Raj |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Ochratoxin A
ochratoxin Aflatoxin Aflatoxin B1 animal structures silymarin Health Toxicology and Mutagenesis clinoptilolite Saccharomyces cerevisiae Toxicology Feed conversion ratio Article Bacillus licheniformis 03 medical and health sciences Basal (phylogenetics) chemistry.chemical_compound Random Allocation Animal science Animals Mycotoxin Ochratoxin 030304 developmental biology broiler chickens Bacillus subtilis 0303 health sciences biology 0402 animal and dairy science Broiler Mycotoxicosis food and beverages aflatoxin 04 agricultural and veterinary sciences biology.organism_classification gut health 040201 dairy & animal science Animal Feed Ochratoxins chemistry Zeolites Medicine Chickens |
| Zdroj: | Toxins, Vol 13, Iss 367, p 367 (2021) Toxins Volume 13 Issue 6 |
| ISSN: | 2072-6651 |
| Popis: | The present study was designed to determine the efficacy of a novel multicomponent mycotoxin detoxifying agent (MMDA) containing modified zeolite (Clinoptilolite), Bacillus subtilis, B. licheniformis, Saccharomyces cerevisiae cell walls and silymarin against the deleterious effects of Aflatoxin B1 (AFB1) and Ochratoxin A (OTA) in broiler chicks. A total of 160 one-day-old Ross 308® broiler chicks were randomly allocated in four treatment groups, with four replicates, according to the following experimental design for 42 days. Group A received a basal diet Group B received a basal diet contaminated with AFB1 and OTA at 0.1 mg/kg and 1 mg/kg, respectively Group C received a basal diet contaminated with AFB1 and OTA and MMDA at 1 g/kg feed, and Group D received a basal diet contaminated with AFB1 and OTA and MMDA at 3 g/kg feed. Results showed that ingested mycotoxins led to significant (p ≤ 0.05) reduction in body weight and feed conversion from 25 days of age, induced histopathological changes, increased the pH of the intestinal content, and altered the biochemical profile of birds with significantly (p ≤ 0.05) increased aspartate aminotransferase (AST) values (p ≤ 0.05). On the other hand, the supplementation of MMDA significantly (p ≤ 0.05) improved the feed conversion ratio (FCR) during the second part of the study, diminished biochemical alterations, reduced pH in jejunal and ileal content, and E. coli counts in the caeca of birds (p ≤ 0.05). It may be concluded that the dietary supplementation of the MMDA partially ameliorated the adverse effects of AFB1 and OTA in broilers and could be an efficient tool in a mycotoxin control program. |
| Databáze: | OpenAIRE |
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