Effect of methimazole treatment on doxorubicin-induced cardiotoxicity in mice
| Autor: | Abdel-Moneim M. Osman, Omimah A. Nassier, Marwa M. Nemnem, Mohamed T. Khayyal, Amany A. Abou-Bakr |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Thyroid Hormones medicine.medical_treatment Cardiomyopathy Pharmacology Toxicology Mice Antithyroid Agents Internal medicine medicine Animals Outbred Strains Animals Creatine Kinase MB Form Doxorubicin Carcinoma Ehrlich Tumor Cardiotoxicity Chemotherapy Antibiotics Antineoplastic Methimazole biology L-Lactate Dehydrogenase business.industry Antithyroid agent Myocardium Troponin I Heart General Medicine medicine.disease Endocrinology Heart failure Toxicity biology.protein Creatine kinase Drug Therapy Combination Female Drug Screening Assays Antitumor business Cardiomyopathies Neoplasm Transplantation Food Science medicine.drug |
| Zdroj: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 47(10) |
| ISSN: | 1873-6351 |
| Popis: | The major limiting factor in long-term administration of doxorubicin is the development of cumulative dose-dependent cardiomyopathy and congestive heart failure that limit the use of this drug. The present study was undertaken to find out the chemo protective role of methimazole against doxorubicin-induced cardiotoxicity in experimental animals. In the present study, doxorubicin treatment in a dose of 3 mg/kg, i.p., every other day for six doses showed a significant 2.6-, 3- and 10.5-fold increase in the cardiac enzyme activities CK-MB and LDH and troponin-I, respectively, in the serum of the animals. Histopathological investigation of heart tissues showed swollen muscle fibers with interstitial edema and inflammatory exudate. Pretreatment of the animals with methimazole at a dose level of 40 mg/kg, i.p., 30 min before doxorubicin, returned the cardiac enzyme levels to nearly normal value with partial reversal of the inflammatory lesions and the swollen muscle fibers induced by doxorubicin. Moreover, methimazole pretreatment, decreased the doxorubicin level in the heart tissues with a significant increase in plasma level and non significant effect on doxorubicin level in tumor cells. At the same time, methimazole pretreatment did not significantly interfere with the antitumor activity of doxorubicin. |
| Databáze: | OpenAIRE |
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