Thiamine Level in Type I and Type II Diabetes Mellitus Patients: A Comparative Study Focusing on Hematological and Biochemical Evaluations
| Autor: | Madiha Ariff, Farheen Shaikh, Jamil Ahmed Siddiqui, Adnan Anwar, Muhammad Ahmed Azmi, Ghazala Panhwar |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
030204 cardiovascular system & hematology Carbohydrate metabolism Gastroenterology vitamin b1 Diabetic nephropathy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Diabetes mellitus Internal medicine Internal Medicine diabetes mellitus type i Medicine diabetes mellitus type ii Triglyceride business.industry Therapeutic effect General Engineering Hematology medicine.disease chemistry thiamine level Thiamine Preventive Medicine Hemoglobin business 030217 neurology & neurosurgery Lipoprotein |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Objective Diabetes has been found to be associated with low levels of thiamine stores in the body, as thiamine directly affects carbohydrate metabolism. Amplified renal clearance of thiamine has been found in both type I and type II diabetic patients. It has been shown that high-dose thiamine therapy may have a therapeutic effect on early-stage diabetic nephropathy. The aim of this study was to evaluate various biochemical parameters and serum thiamine levels in type I and type II diabetic patients and compare them with a healthy control group. Methods A case-control study was carried out in the diabetic out-patient multi-centers in Karachi. A total of 90 participants were selected by using a non-probability convenient sampling technique and divided into three groups, each with 30 subjects. Group A included healthy non-diabetic subjects, while group B included subjects with type I diabetes mellitus (DM), and group C included subjects with type II DM. After receiving informed consent, blood samples were collected from all the participants for hematological and biochemical evaluation. The duration of the study was eight months. Results The study results revealed that the patients with type II DM had significantly higher mean fasting blood sugar (FBS), random blood sugar (RBS), and hemoglobin A1c (HbA1c) levels than those with type I DM or the control group (p |
| Databáze: | OpenAIRE |
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