Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance
| Autor: | Saki Harada, Hiroyoshi Sei, Noriyuki Shimizu, Airi Otsuka, Tetsuya Shiuchi, Seiji Nishino, Sachiko Chikahisa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Sleep Wake Disorders medicine.medical_specialty lcsh:Medicine Mice Transgenic Histamine H1 receptor Carbohydrate metabolism Energy homeostasis Article Impaired glucose tolerance 03 medical and health sciences Random Allocation 0302 clinical medicine Internal medicine Glucose Intolerance medicine Glucose homeostasis Animals Homeostasis Mast Cells lcsh:Science Glucose tolerance test Sleep disorder Mice Inbred ICR Multidisciplinary medicine.diagnostic_test business.industry lcsh:R Brain Glucose Tolerance Test medicine.disease Mast cell Disease Models Animal 030104 developmental biology Endocrinology medicine.anatomical_structure Glucose Adipose Tissue Chronic Disease Histamine H1 Antagonists lcsh:Q business 030217 neurology & neurosurgery Stress Psychological |
| Zdroj: | Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-017-14162-w |
| Popis: | We have developed a chronic mild stress (MS) mouse model by simply rearing mice on a wire net for 3 weeks and investigated the effects of MS on glucose homeostasis and sleep. MS mice showed impaired glucose tolerance and disturbed sleep. One-week treatment with a histamine H1 receptor antagonist (H1RA) ameliorated the glucose intolerance and improved sleep quality in MS mice. MS mice showed an increased number of mast cells in both adipose tissue and the brain. Inhibition of mast cell function ameliorated the impairment in both glucose tolerance and sleep. Together, these findings indicate that mast cells may represent an important pathophysiological mediator in sleep and energy homeostasis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |