The Association of Small Dense Low-Density Lipoprotein Cholesterol and Coronary Heart Disease in Subjects at High Cardiovascular Risk
| Autor: | Jun Hata, Mao Shibata, Takanori Honda, Haruhiko Osawa, Daigo Yoshida, Takanari Kitazono, Kenichi Goto, Toshiharu Ninomiya, Satoko Sakata, Mayu Higashioka |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Coronary Disease 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Diabetes mellitus Internal Medicine Medicine Humans Prospective Studies Prospective study Prospective cohort study Risk assessment Aged High-risk population business.industry Proportional hazards model Cholesterol Biochemistry (medical) Hazard ratio Cholesterol LDL Middle Aged medicine.disease Confidence interval Coronary heart disease chemistry Heart Disease Risk Factors Cardiology Original Article Female Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery Small dense LDL cholesterol Biomarkers Kidney disease Lipoprotein |
| Zdroj: | Journal of Atherosclerosis and Thrombosis |
| ISSN: | 1880-3873 1340-3478 |
| Popis: | Aim The present study aims to investigate the association between serum small dense low-density lipoprotein (sdLDL) cholesterol level and the development of coronary heart disease (CHD) in subjects at high cardiovascular risk. Methods A total of 3,080 participants without prior cardiovascular disease (CVD), aged ≥ 40 years, were followed up for a median of 8.3 years, which were divided into two groups, those with serum sdLDL cholesterol levels of ＜35 mg/dL or ≥ 35 mg/dL. Then, subjects were stratified by the status of diabetes, CVD-related comorbidities (defined as the presence of diabetes, chronic kidney disease, or peripheral artery disease), and the CVD risk assessment according to the Japan Atherosclerosis Society Guidelines. The hazard ratios (HRs) and 95% confidence intervals (CIs) were computed using a Cox proportional hazards model. Results During the follow-up, 79 subjects developed CHD. The risk for incident CHD was higher in subjects with serum sdLDL cholesterol of ≥ 35 mg/dL than those with sdLDL cholesterol of ＜35 mg/dL (HR 2.09, 95%CI 1.26-3.45) after adjusting for traditional risk factors. In the subgroup analyses, the multivariable-adjusted HR for incident CHD increased significantly in those with serum sdLDL cholesterol of ≥ 35 mg/dL among subjects with diabetes (HR 2.76, 95%CI 1.09-7.01), subjects with CVD-related comorbidities (HR 2.60, 95%CI 1.21-5.58), and high-risk category defined as the presence of CVD-related comorbidities or a Suita score of ≥ 56 points (HR 1.93, 95%CI 1.02-3.65). Conclusions Elevated serum sdLDL cholesterol was associated with the development of CHD even in subjects at high cardiovascular risk. |
| Databáze: | OpenAIRE |
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