Effects of Flavonoid-Containing Preparation Extralife on Hydrogen Peroxide Production and Functioning of Mitochondrial ATP-Dependent Potassium Channel
Autor: | Galina D. Mironova, E. I. Lezhnev, L. D. Luk'yanova, S. V. Murzaeva, S. P. Belova |
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Rok vydání: | 2013 |
Předmět: |
medicine.medical_treatment
Flavonoid Malates Succinic Acid Glutamic Acid Mitochondrion Antioxidants Mitochondria Heart General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Adenosine Triphosphate KATP Channels Rotenone Respiration Adaptogen Potassium Channel Blockers High doses medicine Animals Rats Wistar Hydrogen peroxide chemistry.chemical_classification Plant Extracts Low dose Hydrogen Peroxide General Medicine Potassium channel Rats chemistry Biochemistry Hydroxy Acids Decanoic Acids |
Zdroj: | Bulletin of Experimental Biology and Medicine. 155:767-770 |
ISSN: | 1573-8221 0007-4888 |
DOI: | 10.1007/s10517-013-2248-4 |
Popis: | Extralife, a Pentaphylloides fruticos extract, in concentrations of 0.005-10 μg/ml dose-dependently increased H2O2 production in rat heart mitochondria in the presence of respiration substrates. Extralife decreased ATP-induced accumulation of H2O2 related to inhibition of mitochondrial ATP-dependent potassium channel. This effect was observed only at low doses of the adaptogen (0.05-3 μg/ml). High doses of the substance (5-10 μg/ml) did not abolish ATP-dependent production of H2O2 and increased the rate of H2O2 generation by the mitochondria. We concluded that Extralife in trace concentrations could activate mitochondrial ATP-dependent potassium channel and decrease H2O2 accumulation in the mitochondria. |
Databáze: | OpenAIRE |
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