Effects of Flavonoid-Containing Preparation Extralife on Hydrogen Peroxide Production and Functioning of Mitochondrial ATP-Dependent Potassium Channel

Autor: Galina D. Mironova, E. I. Lezhnev, L. D. Luk'yanova, S. V. Murzaeva, S. P. Belova
Rok vydání: 2013
Předmět:
Zdroj: Bulletin of Experimental Biology and Medicine. 155:767-770
ISSN: 1573-8221
0007-4888
DOI: 10.1007/s10517-013-2248-4
Popis: Extralife, a Pentaphylloides fruticos extract, in concentrations of 0.005-10 μg/ml dose-dependently increased H2O2 production in rat heart mitochondria in the presence of respiration substrates. Extralife decreased ATP-induced accumulation of H2O2 related to inhibition of mitochondrial ATP-dependent potassium channel. This effect was observed only at low doses of the adaptogen (0.05-3 μg/ml). High doses of the substance (5-10 μg/ml) did not abolish ATP-dependent production of H2O2 and increased the rate of H2O2 generation by the mitochondria. We concluded that Extralife in trace concentrations could activate mitochondrial ATP-dependent potassium channel and decrease H2O2 accumulation in the mitochondria.
Databáze: OpenAIRE