Exposure to Traffic and Left Ventricular Mass and Function
| Autor: | Ana V. Diez Roux, Victor C. Van Hee, Sara D. Adar, Lianne Sheppard, R. Graham Barr, Edward A. Gill, Adam A. Szpiro, David A. Bluemke, Joel D. Kaufman |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Heart disease Systole Magnetic Resonance Imaging Cine Blood Pressure E. Environmental and Occupational Lung Disease Critical Care and Intensive Care Medicine Residence Characteristics Cardiac magnetic resonance imaging Air Pollution Intensive care Internal medicine medicine Humans Prospective Studies Aged Vehicle Emissions Aged 80 and over medicine.diagnostic_test business.industry Racial Groups Stroke Volume Environmental Exposure Environmental exposure Stroke volume Middle Aged medicine.disease United States Surgery Cross-Sectional Studies Blood pressure Heart failure Cardiology Female Hypertrophy Left Ventricular business |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 179:827-834 |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/rccm.200808-1344oc |
| Popis: | Ambient air pollution has been associated with heart failure morbidity and mortality. The mechanisms responsible for these associations are unknown but may include the effects of traffic-related pollutants on vascular or autonomic function.We assessed the cross-sectional relation between long-term air pollution, traffic exposures, and important end-organ measures of alterations in cardiac function-left ventricular mass index (LVMI) and ejection fraction-in the Multi-Ethnic Study of Atherosclerosis, a multicenter study of adults without previous clinical cardiovascular disease.A total of 3,827 eligible participants (aged 45-84 yr) underwent cardiac magnetic resonance imaging between 2000 and 2002. We estimated air pollution exposures using residential proximity to major roadways and interpolated concentrations of fine particulate matter (less than 2.5 microns in diameter). We examined adjusted associations between these exposures and left ventricular mass and function.Relative to participants living more than 150 m from a major roadway, participants living within 50 m of a major roadway showed an adjusted 1.4 g/m(2) (95% CI, 0.3-2.5) higher LVMI, a difference in mass corresponding to a 5.6 mm Hg greater systolic blood pressure. Ejection fraction was not associated with proximity to major roadways. Limited variability in estimates of fine particulate matter was observed within cities, and no associations with particulate matter were found for either outcome after adjustment for center.Living in close proximity to major roadways is associated with higher LVMI, suggesting chronic vascular end-organ damage from a traffic-related environmental exposure. Air pollutants or another component of roadway proximity, such as noise, could be responsible. |
| Databáze: | OpenAIRE |
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