Alterations in glial fibrillary acidic protein immunoreactivity in the upper dorsal horn of the rat spinal cord in the course of transganglionic degenerative atrophy and regenerative proliferation
| Autor: | Ferenc Hajós, Bert Csillik, Elizabeth Knyihár-Csillik |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Wallerian degeneration Nerve Crush medicine.medical_treatment Central nervous system macromolecular substances Biology Immunoenzyme Techniques Atrophy Reference Values Glial Fibrillary Acidic Protein medicine Animals Axon Glial fibrillary acidic protein General Neuroscience Rhizotomy Rats Inbred Strains Anatomy medicine.disease Spinal cord Sciatic Nerve Nerve Regeneration Rats medicine.anatomical_structure nervous system Spinal Cord Nerve Degeneration biology.protein Female Axotomy |
| Zdroj: | Neuroscience letters. 117(1-2) |
| ISSN: | 0304-3940 |
| Popis: | Transection of a peripheral nerve induces marked increase in the glial fibrillary acidic protein (GFAP) immunoreactivity in the ipsilateral, segmentally related upper dorsal horn. Increase of GFAP immunoreaction is similar to, but not identical with, that observed after dorsal rhizotomy. If the peripheral nerve succeeds in regenerating, GFAP immunoreactivity in the upper dorsal horn returns to normal. It is concluded that the amount and distribution of GFAP is determined by transganglionic degenerative atrophy, Wallerian degeneration and regenerative proliferation of dorsal root axon terminals, respectively. |
| Databáze: | OpenAIRE |
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