Mast Cells: A Pivotal Role in Pulmonary Fibrosis
| Autor: | Stefan Worgall, Nathan O'Connor, Dascher Branch-Elliman, Randi B. Silver, Robert J. Kaner, Arul Veerappan, Brendon M. Stiles, Jacqueline Brazin, Albert Jung, David McGee, Alicia C. Reid, Barbara D. Summers |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Pulmonary Fibrosis Blotting Western Radioimmunoassay Enzyme-Linked Immunosorbent Assay Biology Bleomycin Receptor Angiotensin Type 1 Immunoenzyme Techniques Transforming Growth Factor beta1 Mice chemistry.chemical_compound Renin Pulmonary fibrosis Genetics medicine Animals Humans Mast Cells Lung Molecular Biology Cell Proliferation Mice Knockout Antibiotics Antineoplastic Angiotensin II receptor type 1 Inflammation & Host Response to Infection Angiotensin II Degranulation Cell Biology General Medicine Fibroblasts Mast cell medicine.disease Rats medicine.anatomical_structure chemistry Immunology Collagen Histamine Transforming growth factor |
| Zdroj: | DNA and Cell Biology. 32:206-218 |
| ISSN: | 1557-7430 1044-5498 |
| DOI: | 10.1089/dna.2013.2005 |
| Popis: | Pulmonary fibrosis is characterized by an inflammatory response that includes macrophages, neutrophils, lymphocytes, and mast cells. The purpose of this study was to evaluate whether mast cells play a role in initiating pulmonary fibrosis. Pulmonary fibrosis was induced with bleomycin in mast-cell-deficient WBB6F1-W/W(v) (MCD) mice and their congenic controls (WBB6F1-(+)/(+)). Mast cell deficiency protected against bleomycin-induced pulmonary fibrosis, but protection was reversed with the re-introduction of mast cells to the lungs of MCD mice. Two mast cell mediators were identified as fibrogenic: histamine and renin, via angiotensin (ANG II). Both human and rat lung fibroblasts express the histamine H1 and ANG II AT1 receptor subtypes and when activated, they promote proliferation, transforming growth factor β1 secretion, and collagen synthesis. Mast cells appear to be critical to pulmonary fibrosis. Therapeutic blockade of mast cell degranulation and/or histamine and ANG II receptors should attenuate pulmonary fibrosis. |
| Databáze: | OpenAIRE |
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