Long-term supplementation with n-3 fatty acids, I: Effect on blood lipids, haemostasis and blood pressure
| Autor: | Jørn Dyerberg, K. Varming, Lervang Hh, Erik Berg Schmidt, Poul Henning Madsen |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Time Factors Platelet Function Tests medicine.medical_treatment Lipoproteins Clinical Biochemistry Blood lipids Blood Pressure Fish Oils Von Willebrand factor Bleeding time Internal medicine Fibrinolysis medicine Humans Blood Coagulation chemistry.chemical_classification Hemostasis biology medicine.diagnostic_test General Medicine Middle Aged Fish oil Dietary Fats Lipids Endocrinology Blood pressure chemistry biology.protein Fatty Acids Unsaturated lipids (amino acids peptides and proteins) Female Polyunsaturated fatty acid |
| Zdroj: | Scandinavian journal of clinical and laboratory investigation. 52(3) |
| ISSN: | 0036-5513 |
| Popis: | The effect of dietary supplementation with 4 g of n-3 polyunsaturated fatty acids (PUFA) daily for 9 months on blood pressure, plasma lipids and lipoproteins, platelet function, coagulation and fibrinolysis was studied in 24 healthy volunteers. Each variable was determined before, after 6 weeks and 9 months of supplementation with n-3 PUFA, and 3 months after the supplementation period had ended. Systolic and diastolic blood pressure declined after intake of n-3 PUFAs. Plasma triglycerides were reduced, and there was a trend towards an increase in HDL-cholesterol after 9 months of supplementation, while total cholesterol, LDL-cholesterol and apolipoproteins A1 and B were unaltered. The bleeding time was increased, and plasma levels of von Willebrand factor decreased after 9 months supplementation with n-3 PUFA. Fibrinogen levels increased, while fibrinolysis was reduced after 9 months supplementation with n-3 PUFA. Overall, no clear benefit on lipid pattern and haemostasis was achieved with respect to development of coronary heart disease. |
| Databáze: | OpenAIRE |
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