Diagnostic value of platelet indices and bone marrow megakaryocytic parameters in immune thrombocytopenic purpura
| Autor: | Huan-Zhu Chen, Xiaoyang Jiao, Xiao-Lan Chang, Yue-Ting Tang, Qing-Dong Xie, Ping He, Ya-Zhen Li |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Adolescent 030204 cardiovascular system & hematology Positive correlation Gastroenterology 03 medical and health sciences Young Adult 0302 clinical medicine Immune system immune system diseases Bone Marrow hemic and lymphatic diseases Internal medicine medicine Humans Platelet Mean platelet volume Retrospective Studies Purpura Thrombocytopenic Idiopathic Platelet indices Chemistry Platelet Count Platelet Distribution Width Hematology General Medicine Middle Aged medicine.disease Thrombocytopenic purpura medicine.anatomical_structure 030220 oncology & carcinogenesis Immunology Female Bone marrow Mean Platelet Volume Megakaryocytes |
| Zdroj: | Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 28(1) |
| ISSN: | 1473-5733 |
| Popis: | Platelet indices could mirror megakaryopoietic activity in immune thrombocytopenic purpura (ITP), but its specificity and sensitivity need to be studied. The diagnostic performance of platelet indices was analyzed by receiver-operating characteristic curves, and the probability of true positive (sensitivity) and true negative (specificity) in predicting ITP, myelodysplasia, or controls was determined. Mean platelet volume (MPV) was higher, whereas plateletcrit (PCT) was significantly lower in ITP than in myelodysplasia and controls. The platelet distribution width in ITP patients was lower than in myelodysplasia, but higher than in controls. Increased megakaryocytes were only observed in ITP. A strong positive correlation was found between MPV and quantities of granular megakaryocytes, whereas a negative relationship existed between MPV and platelet-form megakaryocytes. In receiver-operating characteristic analysis, MPV and PCT gave a sensitivity of 70.3% (89.8%) and specificity of 74.8% (84.7%) at a cutoff of 9.35 (0.085) in diagnosis of ITP. Combined parallel test of MPV and PCT increased the sensitivity to 97.5 with 64.1% specificity, whereas series test increased the specificity to 94.7 with 62.7% sensitivity. Our results suggest that MPV, PCT, and platelet distribution width represent megakaryopoietic activity in bone marrow and may be reliable markers in ITP diagnosis. |
| Databáze: | OpenAIRE |
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