CDK4 Inhibitors Thwart Immunity by Inhibiting Phospho-RB-NF-κB Complexes
| Autor: | Seung J. Kim, Frederick A. Dick, Samuel Asfaha |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
biology Cell Retinoblastoma protein NF-κB Cell Biology Pediatrics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.anatomical_structure chemistry Transcription (biology) Cancer cell Cancer research medicine biology.protein Phosphorylation Signal transduction Molecular Biology 030217 neurology & neurosurgery B7-H1 Antigen 030304 developmental biology |
| Zdroj: | Paediatrics Publications |
| ISSN: | 1097-2765 |
| DOI: | 10.1016/j.molcel.2018.12.012 |
| Popis: | PD-L1 plays a central role in immune recognition of cancer cells. In this issue of Molecular Cell, Jin et al. (2019) report that a phosphorylated retinoblastoma protein contacts the DNA-binding domain of p65 NF-kB, thereby blocking transcription of PD-L1. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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