SERUM IgM AND IgG RESPONSES IN POSTNATALLY ACQUIRED RUBELLA
| Autor: | Duncan J. Watson, J. M. Best, Jangu E. Banatvala |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
Adult
Immunodiffusion Time Factors Globulin Rubella Immunoglobulin G Pregnancy Centrifugation Density Gradient medicine Humans Conceptus Pregnancy Complications Infectious Mercaptoethanol biology business.industry Complement Fixation Tests Infant Newborn General Medicine Hemagglutination Inhibition Tests medicine.disease Titer Immunoglobulin M Antibody Formation Immunology biology.protein Female Antibody business |
| Zdroj: | The Lancet. 294:65-68 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(69)92386-1 |
| Popis: | Sucrose-density-gradient studies on sera from patients recently convalescent from rubella showed that specific IgM could be detected by haemagglutination-inhibition tests for up to 20 days from the onset of illness. This was associated with a significant increase in the concentrations of total IgM but not IgG, the IgM response being maximal 5-14 days after the onset of illness. After a month, only IgG could be detected. Complement-fixation antibodies, even when appearing early, consisted of IgG alone. Serum-total-IgG concentrations showed little variation in healthy patients throughout pregnancy, while IgM concentrations were reduced during the second trimester of pregnancy. The presence of a rubella-infected conceptus did not produce an unusually prolonged IgM response. Reduction in antibody titre in sera after treatment with 2-mercaptoethanol provided a less reliable method for demonstrating recent infection, since reductions in titre were associated usually with significantly raised total-IgM levels. |
| Databáze: | OpenAIRE |
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