Association Between Perceived Stress and Plasma B-Type Natriuretic Peptide Concentrations
| Autor: | Yutaka Motohashi, Yoshihiro Kaneko, Hiroshi Ito, Shinya Tosa, Hiroyuki Watanabe, Megumi Koizumi, Toshimitsu Kosaka, Hitoshi Hasegawa |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Heart Diseases Heart disease medicine.drug_class Cardiovascular risk factors Blood Pressure Electrocardiography symbols.namesake Japan Risk Factors Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Humans Medical history Life Style Aged Aged 80 and over Sex Characteristics Heart disease risk business.industry General Medicine Middle Aged Anthropometry medicine.disease Health Surveys Self Concept Cross-Sectional Studies Endocrinology Bonferroni correction Blood pressure symbols Female Cardiology and Cardiovascular Medicine business Stress Psychological |
| Zdroj: | Circulation Journal. 73:1055-1061 |
| ISSN: | 1347-4820 1346-9843 |
| DOI: | 10.1253/circj.cj-08-0986 |
| Popis: | Background: Many patients with heart disease continue to have cardiac events despite receiving optimal treatments for traditional risk factors. Consequently, non-traditional risk factors for heart disease, such as perceived stress, have attracted attention. Associations between perceived stress and plasma B-type natriuretic peptide (BNP) were explored, while controlling for traditional heart disease risk factors. Methods and Results: This cross-sectional study examined 360 male and 446 female (age, >40 years) residents of a rural Japanese community who received annual health checkups in 2006. A lifestyle questionnaire was used to obtain information regarding perceived stress and medical history, and routine anthropometric and blood pressure measurements and a laboratory assessment of cardiovascular risk factors, including plasma BNP concentrations and an electrocardiogram, were done. After adjusting for traditional heart disease risk factors, multiple regression analysis showed that perceived stress was associated with BNP concentrations, particularly in women (F=6.12, P=0.026). In addition, multiple tests using Bonferroni's procedure showed that BNP concentrations decreased with perceived stress level in men and women. Similar trends were observed in the sub-analyses of subjects with and without known heart disease. Conclusions: Perceived stress in our study was negatively associated with plasma BNP concentrations, independently of traditional heart disease risk factors. (Circ J 2009; 73: 1055-1061 |
| Databáze: | OpenAIRE |
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