Immunohistochemical Distinction Between Merkel Cell Carcinoma and Small Cell Carcinoma of the Lung
| Autor: | Prodromos Hytiroglou, Georgios Karkavelas, Ioannis Kostopoulos, Constantine S. Papadimitriou, Mattheos Bobos |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male endocrine system Pathology medicine.medical_specialty Lung Neoplasms Skin Neoplasms Receptor ErbB-2 Thyroid Nuclear Factor 1 Synaptophysin Thyroid Gland Keratin-20 Dermatology Small-cell carcinoma Pathology and Forensic Medicine Cytokeratin Neurofilament Proteins Biomarkers Tumor Chromogranins medicine Carcinoma Humans Vimentin Carcinoma Small Cell Aged Aged 80 and over biology Merkel cell carcinoma Keratin 20 Keratin-7 S100 Proteins Nuclear Proteins General Medicine Middle Aged respiratory system medicine.disease Immunohistochemistry CD56 Antigen Carcinoma Merkel Cell Proto-Oncogene Proteins c-kit medicine.anatomical_structure Phosphopyruvate Hydratase biology.protein Keratins Female Small Cell Lung Carcinoma Merkel cell Transcription Factors |
| Zdroj: | The American Journal of Dermatopathology. 28:99-104 |
| ISSN: | 0193-1091 |
| Popis: | We assessed the usefulness of several immunohistochemical stains in distinguishing these two neoplasms, including cytokeratin 7, cytokeratin 20 (CK20), neuron-specific enolase, chromogranin, synaptophysin, neurofilaments (NF), thyroid-transcription factor-1 (TTF-1), CD56 antigen, S-100 protein, vimentin, c-erbB-2 oncoprotein, and CD117 antigen. All 13 cases of Merkel cell carcinoma evaluated were positive for CK20, and negative for TTF-1. Twelve of 13 Merkel cell carcinoma cases were positive for NF. Eleven of 13 cases of small cell lung carcinoma were positive for TTF-1. All small cell lung carcinoma cases were negative for NF, and all but one were negative for CK20. In terms of the remaining antigens, there were no differences of significance between the two neoplasms. These findings suggest that a set of three immunohistochemical stains, including CK20, NF, and TTF-1, is useful in affording a distinction between Merkel cell carcinoma and small cell lung carcinoma. |
| Databáze: | OpenAIRE |
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