Elevated levels of plasma osteoprotegerin are associated with all-cause mortality risk and atherosclerosis in patients with stages 3 to 5 chronic kidney disease

Autor: M. M. Nascimento, Miguel C. Riella, Bengt Lindholm, Shirley Yumi Hayashi
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
Physiology
medicine.medical_treatment
Kaplan-Meier Estimate
Carotid Intima-Media Thickness
Severity of Illness Index
Biochemistry
Cause of Death
Chronic kidney disease
Troponin I
General Pharmacology
Toxicology and Pharmaceutics
lcsh:QH301-705.5
Aged
80 and over
lcsh:R5-920
General Neuroscience
General Medicine
Middle Aged
Echocardiography
Doppler
C-Reactive Protein
Heart Function Tests
Female
Hemodialysis
medicine.symptom
lcsh:Medicine (General)
Brazil
Adult
Risk
Cardiac function curve
musculoskeletal diseases
medicine.medical_specialty
Adolescent
Immunology
Biophysics
Ocean Engineering
Inflammation
Peritoneal dialysis
Young Adult
Osteoprotegerin
Internal medicine
medicine
Humans
Clinical Investigation
Renal Insufficiency
Chronic
Mortality
Survival rate
Aged
Interleukin-6
business.industry
Cell Biology
medicine.disease
Atherosclerosis
Fibroblast Growth Factors
Fibroblast Growth Factor-23
Endocrinology
lcsh:Biology (General)
Multivariate Analysis
business
Biomarkers
Kidney disease
Zdroj: Brazilian Journal of Medical and Biological Research v.47 n.11 2014
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Vol 47, Iss 11, Pp 995-1002 (2014)
Brazilian Journal of Medical and Biological Research, Volume: 47, Issue: 11, Pages: 1002-995, Published: 22 AUG 2014
Popis: Osteoprotegerin (OPG) regulates bone mass by inhibiting osteoclast differentiation and activation, and plays a role in vascular calcification. We evaluated the relationship between osteoprotegerin levels and inflammatory markers, atherosclerosis, and mortality in patients with stages 3-5 chronic kidney disease. A total of 145 subjects (median age 61 years, 61% men; 36 patients on hemodialysis, 55 patients on peritoneal dialysis, and 54 patients with stages 3-5 chronic kidney disease) were studied. Clinical characteristics, markers of mineral metabolism (including fibroblast growth factor-23 [FGF-23]) and inflammation (high-sensitivity C-reactive protein [hsCRP] and interleukin-6 [IL-6]), and the intima-media thickness (IMT) in the common carotid arteries were measured at baseline. Cardiac function was assessed by color tissue Doppler echocardiography. After 36 months follow-up, the survival rate by Kaplan-Meier analysis was significantly different according to OPG levels (χ 2=14.33; P=0.002). Increased OPG levels were positively associated with IL-6 (r=0.38, P
Databáze: OpenAIRE
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