Oral administration of L-arginine decreases blood pressure and increases renal excretion of sodium and water in renovascular hypertensive rats
| Autor: | Nazaré Souza Bissoli, J. G. P. Pires, Antonio M. Cabral, Sonia Alves Gouvea, Gláucia R. Abreu, Margareth Ribeiro Moysés |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Physiology Immunology Biophysics Diuresis Natriuresis L-arginine Arginine Biochemistry Renovascular hypertension Excretion Body Water Internal medicine medicine Animals General Pharmacology Toxicology and Pharmaceutics Rats Wistar lcsh:QH301-705.5 Sodium excretion Kidney lcsh:R5-920 business.industry General Neuroscience Sodium Nitric oxide Cell Biology General Medicine medicine.disease Rats Renal physiology Disease Models Animal Mean blood pressure Blood pressure Endocrinology medicine.anatomical_structure Hypertension Renovascular lcsh:Biology (General) Anesthesia business lcsh:Medicine (General) |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Vol 36, Iss 7, Pp 943-949 (2003) Brazilian Journal of Medical and Biological Research, Volume: 36, Issue: 7, Pages: 943-949, Published: JUL 2003 Brazilian Journal of Medical and Biological Research v.36 n.7 2003 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
| Popis: | The two-kidney, one-clip renovascular (2K1C) hypertension model is characterized by a reduction in renal flow on the clipped artery that activates the renin-angiotensin system. Endothelium dysfunction, including diminished nitric oxide production, is also believed to play a role in the pathophysiology of this model. Some studies have shown an effect of L-arginine (L-Arg, a nitric oxide precursor) on hypertension. In the present study we determined the ability of L-Arg (7 days of treatment) to reduce blood pressure and alter renal excretions of water, Na+ and K+ in a model of 2K1C-induced hypertension. Under ether anesthesia, male Wistar rats (150-170 g) had a silver clip (0.20 mm) placed around the left renal artery to produce the 2K1C renovascular hypertension model. In the experimental group, the drinking water was replaced with an L-Arg solution (10 mg/ml; average intake of 300 mg/day) from the 7th to the 14th day after surgery. Sham-operated rats were used as controls. At the end of the treatment period, mean blood pressure was measured in conscious animals. The animals were then killed and the kidneys were removed and weighed. There was a significant reduction of mean blood pressure in the L-Arg-treated group when compared to control (129 ± 7 vs 168 ± 6 mmHg, N = 8-10 per group; P |
| Databáze: | OpenAIRE |
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