Paternal radiation exposure and leukaemia in offspring: the Ontario case-control study
| Autor: | T W Anderson, E A Clarke, John R. McLaughlin, J P Ashmore, Will D. King |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Adolescent Offspring Radiation Dosage Fathers Nuclear Reactors Risk Factors Occupational Exposure Epidemiology Odds Ratio Medicine Humans Child General Environmental Science Leukemia Radiation-Induced Ontario business.industry General Engineering Case-control study Infant Newborn Infant General Medicine Odds ratio Confidence interval Radiation exposure El Niño Case-Control Studies Child Preschool General Earth and Planetary Sciences Female Preconception Care business Record linkage Demography Research Article |
| Zdroj: | BMJ (Clinical research ed.). 307(6910) |
| ISSN: | 0959-8138 |
| Popis: | OBJECTIVES--To test the hypothesis that there is an association between childhood leukaemia and the occupational exposure of fathers to ionising radiation before a child's conception. DESIGN--Case-control study with eight matched controls per case. SETTING--Regions of Ontario, Canada, with an operating nuclear facility. SUBJECTS--Cases were children (age 0-14) who died from or were diagnosed as having leukaemia from 1950 to 1988 and were born to mothers living in the vicinity of an operating nuclear facility. Controls were identified from birth certificates, matched by date of birth and residence at birth. There were 112 cases and 890 controls. MAIN OUTCOME MEASURES--Paternal radiation exposure was determined by a record linkage to the Canadian National Dose Registry. RESULTS--Six fathers of cases and 53 fathers of controls had had a total whole body dose > 0.0 mSv before the child's conception, resulting in an odds ratio of 0.87 (95% confidence interval 0.32 to 2.34). There was no evidence of an increased leukaemia risk in relation to any exposure period (lifetime or six months or three months before conception) or exposure type (total whole body dose, external whole body dose, or tritium dose), except for radon exposure to uranium miners, which had a large odds ratio that was not significantly different from the null value. CONCLUSIONS--The findings of this study in Ontario did not support the hypothesis that childhood leukaemia is associated with the occupational exposure of fathers to ionising radiation before the child's conception. |
| Databáze: | OpenAIRE |
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