Dopamine Release in the Nonhuman Primate Caudate and Putamen Depends upon Site of Stimulation in the Subthalamic Nucleus
| Autor: | Su Youne Chang, Megan L. Settell, Penelope S. Duffy, Shinho Cho, Erika K. Ross, Hang Joon Jo, Charles D. Blaha, Kevin E. Bennet, Kendall H. Lee, Ju Ho Jeong, Hoon Ki Min |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Deep brain stimulation Dopamine medicine.medical_treatment Caudate nucleus Stimulation 03 medical and health sciences Imaging Three-Dimensional 0302 clinical medicine Neurochemical Subthalamic Nucleus Neural Pathways Basal ganglia medicine Animals Brain Mapping business.industry General Neuroscience Putamen Articles Macaca mulatta Magnetic Resonance Imaging Electric Stimulation nervous system diseases Subthalamic nucleus surgical procedures operative 030104 developmental biology nervous system Caudate Nucleus business therapeutics Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | The Journal of Neuroscience. 36:6022-6029 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.0403-16.2016 |
| Popis: | Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for medically refractory Parkinson's disease. Although DBS has recognized clinical utility, its biologic mechanisms are not fully understood, and whether dopamine release is a potential factor in those mechanisms is in dispute. We tested the hypothesis that STN DBS-evoked dopamine release depends on the precise location of the stimulation site in the STN and the site of recording in the caudate and putamen. We conducted DBS with miniature, scaled-to-animal size, multicontact electrodes and used functional magnetic resonance imaging to identify the best dopamine recording site in the brains of nonhuman primates (rhesus macaques), which are highly representative of human brain anatomy and circuitry. Real-time stimulation-evoked dopamine release was monitored usingin vivofast-scan cyclic voltammetry. This study demonstrates that STN DBS-evoked dopamine release can be reduced or increased by redirecting STN stimulation to a slightly different site.SIGNIFICANCE STATEMENTElectrical stimulation of deep structures of the brain, or deep brain stimulation (DBS), is used to modulate pathological brain activity. However, technological limitations and incomplete understanding of the therapeutic mechanisms of DBS prevent personalization of this therapy and may contribute to less-than-optimal outcomes. We have demonstrated that DBS coincides with changes in dopamine neurotransmitter release in the basal ganglia. Here we mapped relationships between DBS and changes in neurochemical activity. Importantly, this study shows that DBS-evoked dopamine release can be reduced or increased by refocusing the DBS on a slightly different stimulation site. |
| Databáze: | OpenAIRE |
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