Evaluation of a labdane diterpene forskolin isolated from
| Autor: | Krishnaswamy Thenmozhi, Mohamed Soliman Elshikh, S. Paulsamy, Venkatachalapathi A, Mohammad Ajmal Ali, Karthika K, Fahad M.A. Al-Hemaid |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0106 biological sciences
0301 basic medicine Antioxidant Solena amplexicaulis medicine.medical_treatment Biology 01 natural sciences Article Labdane 03 medical and health sciences chemistry.chemical_compound Oral administration Antihyperlipidemic medicine lcsh:QH301-705.5 Forskolin Traditional medicine Glycogen Streptozotocin Cucurbitaceae 030104 developmental biology chemistry Antidiabetic lcsh:Biology (General) Diterpene General Agricultural and Biological Sciences 010606 plant biology & botany medicine.drug |
| Zdroj: | Saudi Journal of Biological Sciences, Vol 26, Iss 7, Pp 1710-1715 (2019) Saudi Journal of Biological Sciences |
| ISSN: | 1319-562X |
| Popis: | Solena amplexicaulis (Lam.) Gandhi (Family Cucurbitaceae) is one of the important plant species used by the Irula tribes of Walayar valley of southern Western Ghats, India for the management of diabetes. To confirm the antidiabetic property of S. amplexicaulis, the present study was addressed using crude methanolic leaf extract of S. amplexicaulis (MeOHSa) and its isolated compound, Forskolin against streptozotocin (STZ) induced diabetic rats. The oral glucose tolerance test (OGTT), blood glucose, lipid profile, serum liver markers, antioxidants, hemoglobin and glycogen were evaluated using standard procedure. The oral administration of Forskolin and MeOHSa (600 mg/kg b.w.) for 30 days resulted in significant restoration of all these parameters supported by histopathological observations too. The results clearly suggest that the Forskolin (diterpene) possess potent antidiabetic and antihyperlipidemic activities, which may be considered as a lead molecule for therapeutic purposes, and the source of Forskolin i.e. S. amplexicaulis can be further exploited for pharmaceutical industries. Keywords: Solena amplexicaulis, Cucurbitaceae, Forskolin, Antidiabetic, Antihyperlipidemic, Antioxidant |
| Databáze: | OpenAIRE |
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