Thyroid Cancer in the Pediatric Age in Sicily: Influence of the Volcanic Environment
| Autor: | Giulia Sapuppo, Gabriella Pellegriti, Pasqualino Malandrino, Riccardo Vigneri, Mariacarla Moleti, Fiorenza Gianì, Martina Tavarelli, Sebastiano Squatrito, Marco Russo, Antonio D'angelo, Pierina Richiusa |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Cancer Research Papillary Pediatrics Cohort Studies 0302 clinical medicine Risk Factors Medicine Registries Child Thyroid cancer Sicily geography.geographical_feature_category Thyroid cancer epidemiology Geography Incidence (epidemiology) Incidence Pediatric age General Medicine Oncology 030220 oncology & carcinogenesis Child Preschool Evaluated data Female Standardized rate Pediatric thyroid cancer Thyroid cancer and volcanic environment Adolescent Carcinoma Papillary Humans Infant Infant Newborn Thyroid Neoplasms Volcanic Eruptions Young Adult 03 medical and health sciences Area of residence Preschool geography business.industry fungi Carcinoma medicine.disease Newborn 030104 developmental biology Volcano business Demography |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1791-7530 |
| Popis: | Background/Aim: Pediatric thyroid cancer (TC) is rare but its incidence is increasing. We analyzed incidence and characteristics of pediatric TC in Sicily and comparatively evaluated data from the volcanic and non-volcanic areas. Materials and Methods: All incident pediatric (0-19 years) TCs in Sicily between 2002-2009 were analyzed for the area of residence and compared to data for adults. Results: A total of 54 differentiated TCs (DTC) and nine medullary TCs were diagnosed in Sicily in children between 2002-2009. DTC age standardized rate for the world population (ASRw) was 0.8/105 in females and 0.2/105 in males, with a higher incidence in the volcanic area (ASRw=1.4/105 in females, 0.5/105 in males) vs. the rest of Sicily (ASRw=0.6/105 in females, 0.1/105 in males). Pediatric TCs were larger in size and more frequently with extrathyroid extension and lymph-node involvement in comparison to TCs in adults. Conclusion: In the volcanic environment of Sicily, TC incidence is markedly increased in children, suggesting a short-term effect of unidentified carcinogens of volcanic origin. |
| Databáze: | OpenAIRE |
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