Effect of 5-Fluorouracil on Thymidine Phosphorylase Activity in Model Experiment
| Autor: | Yu. V. Dumanskii, E. V. Khomutov, A. G. Matvienko, I. I. Zinkovich, M. A. Stashkevich |
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| Rok vydání: | 2014 |
| Předmět: |
0301 basic medicine
Male Thymidine phosphorylase activity medicine.medical_treatment Antineoplastic Agents Pharmacology High-performance liquid chromatography General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine medicine Animals Thymidine phosphorylase Rats Wistar Bolus injection Chemotherapy Thymidine Phosphorylase biology Chemistry General Medicine Enzyme assay Rats 030104 developmental biology Liver Fluorouracil 030220 oncology & carcinogenesis Rat liver biology.protein medicine.drug |
| Zdroj: | Bulletin of experimental biology and medicine. 160(5) |
| ISSN: | 1573-8221 |
| Popis: | Variations in thymidine phosphorylase activity in rat liver were studied in 1, 3, 6, 12, and 24 h after intraperitoneal bolus injection of 5-fluorouracil. Enzyme activity was measured by HPLC. A 2-fold decrease in enzyme activity was observed 3 h after 5-fluorouracil administration and persisted for 12 h. This additional effect of the cytostatic should be taken into account in choosing chemotherapy protocol. |
| Databáze: | OpenAIRE |
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