Shunting in AD slows progression of the dementia
| Autor: | Joan Carvalho, Gerald D. Silverberg, Jere Douglas Fellmann, Martha Mayo, Jonathan Williams, Tom A. Saul, Dawn McGuire |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Hematology Neurology Post hoc business.industry medicine.disease lcsh:RC346-429 Shunting Pathogenesis Cellular and Molecular Neuroscience Cerebrospinal fluid Developmental Neuroscience Interstitial fluid Internal medicine medicine Cardiology Dementia business lcsh:Neurology. Diseases of the nervous system |
| Zdroj: | Cerebrospinal Fluid Research, Vol 4, Iss Suppl 1, p S42 (2007) |
| ISSN: | 1743-8454 |
| Popis: | Background The pathogenesis of Alzheimer's disease (AD) may involve impaired clearance of toxic metabolites, e.g. amyloid-beta peptides (Aβ), from the brain via interstitial fluid (ISF) and cerebrospinal fluid (CSF) circulation, and the blood-brain barrier (BBB). If so, then increasing ISF and CSF circulation may improve CSF Aβ clearance and may slow the progression of AD. We tested this hypothesis in a prospective, randomized, double-blind, placebo-controlled trial of low-flow CSF shunting. Our previously reported analysis using the Generalised Estimating Equations showed no effect of CSF shunting. The present report provides post hoc analyses using linear mixedeffects models fit by maximum likelihood. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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