Renin-angiotensin system modulation through enalapril and/or exercise training improves visceral adiposity in obese mice

Autor: Beatriz Alexandre-Santos, D'Angelo Carlo Magliano, Isabele Gomes Giori, Gabriela Rodrigues de Oliveira Medeiros, Carla P. Vieira, Carlos Adam Conte-Junior, Antonio Claudio Lucas da Nobrega, Eliete Dalla Corte Frantz
Rok vydání: 2022
Předmět:
Zdroj: Life Sciences. 291:120269
ISSN: 0024-3205
DOI: 10.1016/j.lfs.2021.120269
Popis: Obesity-related metabolic diseases occur as a result of disruptions in white adipose tissue (WAT) plasticity, especially through visceral fat accumulation and adipocyte hypertrophy. This study aimed to evaluate the impact of renin-angiotensin system (RAS) and bradykinin receptors modulation by enalapril treatment and/or exercise training on WAT morphology and related deleterious outcomes.Male C57BL/6 mice were fed either a standard chow or a high-fat (HF) diet for 16 weeks. At the 8th week, HF-fed animals were divided into sedentary (HF), enalapril treatment (HF-E), exercise training (HF-T), and enalapril treatment plus exercise training (HF-ET) groups. Following the experimental protocol, body mass gain, adiposity index, insulin resistance, visceral WAT morphometry, renin-angiotensin system, and bradykinin receptors were evaluated.The HF group displayed increased adiposity, larger visceral fat mass, and adipocyte hypertrophy, which was accompanied by insulin resistance, overactivation of Ang II/AT1R arm, and favoring of B1R in bradykinin receptors profile. All interventions ameliorated visceral adiposity and related outcomes by favoring the Ang 1-7/MasR arm and the B2R expression in B1R/B2R ratio. However, combined therapy additively reduced Ang II/Ang 1-7 ratio.Our results suggest that Ang 1-7/MasR arm and B2R activation might be relevant targets in the treatment of visceral obesity.
Databáze: OpenAIRE
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