| Autor: |
Panagiotis Karras, Maxime de Waegeneer, Ruchan Karaman, Leticia Sansores-Garcia, Laura Van den Mooter, Inge Mannaerts, Randy L. Johnson, Hanne Hillen, Elisabeth Verboven, Matthias Van Haele, Weronika Kowalczyk, Iván M. Moya, Jun Xie, Tania Roskams, Georg Halder, Jean-Christophe Marine, Leen Van Huffel, Soheil Soheily, Lars Zender, Leo A. van Grunsven, Stefaan Verhulst, Stephanie Anais Castaldo, Ana Algueró-Nadal, Jelle Jacobs, Stein Aerts |
| Přispěvatelé: |
Basic (bio-) Medical Sciences, Liver Cell Biology, Translational Liver Cell Biology |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Science |
| Popis: |
Mixed signals at tumor margins The Hippo signaling pathway has been implicated in tumor growth, sparking interest in the pathway as a potential therapeutic target. In a study of liver cancer in genetically manipulated mice, Moya et al. discovered that the role of this pathway in tumorigenesis is more complex than previously appreciated. They confirmed that activation of the Hippo pathway within tumor cells drives tumor growth; however, they also found that activation of the pathway in adjacent healthy cells has the opposite effect, suppressing tumor growth. Whether tumor cells survive or are eliminated thus appears to depend on competing signals produced by the tumor and surrounding tissue. Science , this issue p. 1029 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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