Delivery of transcription factors as modulators of cell differentiation
| Autor: | Héctor Rilo-Alvarez, Marcos Garcia-Fuentes, Anxo Vidal, Adriana M. Ledo |
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| Rok vydání: | 2021 |
| Předmět: |
Cellular differentiation
Pharmaceutical Science Cell Differentiation 02 engineering and technology Computational biology Cell-Penetrating Peptides Cell fate determination Biology Gene delivery 021001 nanoscience & nanotechnology Regenerative Medicine 030226 pharmacology & pharmacy Regenerative medicine 03 medical and health sciences Transduction (genetics) 0302 clinical medicine Gene expression 0210 nano-technology Reprogramming Transcription factor Transcription Factors |
| Zdroj: | Drug delivery and translational research. 11(2) |
| ISSN: | 2190-3948 |
| Popis: | Fundamental studies performed during the last decades have shown that cell fate is much more plastic than previously considered, and technologies for its manipulation are a keystone for many new tissue regeneration therapies. Transcription factors (TFs) are DNA-binding proteins that control gene expression, and they have critical roles in the control of cell fate and other cellular behavior. TF-based therapies have much medical potential, but their use as drugs depends on the development of suitable delivery technologies that can help them reach their action site inside of the cells. TFs can be used either as proteins or encoded in polynucleotides. When used in protein form, many TFs require to be associated to a cell-penetrating peptide or another transduction domain. As polynucleotides, they can be delivered either by viral carriers or by non-viral systems such as polyplexes and lipoplexes. TF-based therapies have extensively shown their potential to solve many tissue-engineering problems, including bone, cartilage and cardiac regeneration. Yet, their use has expanded beyond regenerative medicine to other prominent disease areas such as cancer therapy and immunomodulation. This review summarizes some of the delivery options for effective TF-based therapies and their current main applications. |
| Databáze: | OpenAIRE |
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