Expansive Arterial Remodeling Is Associated With Increased Neointimal Macrophage Foam Cell Content
| Autor: | Eugen Ivan, Denis Godin, Zorina S. Galis, Richard Magid, Sudeshna Nandi, Chad Johnson, Jaikirshan J. Khatri, Susan M. Lessner |
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| Rok vydání: | 2002 |
| Předmět: |
Carotid Artery Diseases
Male Apolipoprotein E Pathology medicine.medical_specialty Cell Count Matrix metalloproteinase Extracellular matrix Mice Apolipoproteins E Physiology (medical) medicine Animals Macrophage Ligation Foam cell Mice Knockout business.industry Macrophages Tunica intima Immunohistochemistry Pathophysiology Extracellular Matrix Mice Inbred C57BL Disease Models Animal medicine.anatomical_structure Matrix Metalloproteinase 9 Disease Progression Tunica Intima Cardiology and Cardiovascular Medicine business Foam Cells |
| Zdroj: | Circulation. 105:2686-2691 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.0000016825.17448.11 |
| Popis: | Background — Recent observations associate plaque instability with expansive arterial remodeling, suggesting a common driving mechanism. Methods and Results — To demonstrate that macrophages, a characteristic of vulnerable plaques, also assist in expansive remodeling, we compared carotid artery remodeling due to formation of experimental macrophage-rich and macrophage-poor lesions in the flow cessation model in hypercholesterolemic apolipoprotein E knockout (ApoE KO) and wild type (WT) mice. After ligation, macrophages started to rapidly accumulate in ApoE KO but not in WT carotid artery lesions. Macrophage-rich ApoE KO intimal lesions grew fast, typically occluding within 14 days, despite a tripling of the vessel area. Outward remodeling of macrophage-rich ApoE KO arteries positively correlated with macrophage area ( r 2 =0.600, P Conclusions — Our results suggest that macrophages facilitate expansive arterial remodeling through increased matrix degradation by matrix metalloproteinases. This initially favorable remodeling action may eventually increase the vulnerability of macrophage-rich atherosclerotic plaques. |
| Databáze: | OpenAIRE |
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